GNB4 Antibody, Biotin conjugated

Code CSB-PA862056LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GNB4 Polyclonal antibody
Uniprot No.
Target Names
GNB4
Alternative Names
G protein beta 4 subunit antibody; GBB4_HUMAN antibody; GNB 4 antibody; Gnb4 antibody; Guanine nucleotide binding protein (G protein) beta polypeptide 4 antibody; Guanine nucleotide binding protein beta 4 subunit antibody; Guanine nucleotide binding protein beta polypeptide 4 antibody; Guanine nucleotide binding protein beta subunit 4 antibody; Guanine nucleotide binding protein subunit beta 4 antibody; Guanine nucleotide-binding protein subunit beta-4 antibody; Transducin beta chain 4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Guanine nucleotide-binding protein subunit beta-4 protein (105-185AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Gene References into Functions
  1. GNB4 is important for growth of breast cancer cells and a potential target for treatment PMID: 30103729
  2. A novel missense GNB4 variant causes Charcot-Marie-Tooth disease F in two patients, who represent the first record of the disease in the Japanese population. PMID: 28642160
  3. Suggest Gbeta4gamma1 as a modulator of M3 muscarinic receptor signaling. PMID: 25916507
  4. Analysis of GNB4 in an additional 88 unrelated CMT individuals uncovered another de novo mutation. PMID: 23434117
  5. Gbeta4 subunit is coexpressed in physiologically ON-type cone bipolar cells with Ggamma13 and Gbeta3 but is not present in OFF-type bipolar cells. PMID: 12454992
  6. Gbeta4 is widely expressed, located on chromosome 3 with a genomic structure like Gbeta1 to Gbeta3, but different from Gbeta5 PMID: 12782285
  7. Intron-1 haplotypes of GNB4 may, thus, serve as predictive markers for progression and survival of patients suffering from bladder cancer. PMID: 18815590
  8. Intron-1 haplotypes of GNB4 is associated with colorectal carcinoma. PMID: 19414374

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Involvement in disease
Charcot-Marie-Tooth disease, dominant, intermediate type, F (CMTDIF)
Protein Families
WD repeat G protein beta family
Tissue Specificity
Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves.
Database Links

HGNC: 20731

OMIM: 610863

KEGG: hsa:59345

STRING: 9606.ENSP00000232564

UniGene: Hs.173030

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